Lillian Hellman wrote the screenplay for a 1941 film version starring Bette Davis. In 1949, the play was adapted for an opera entitled Regina by Marc Blitzstein.
In 1946, Hellman wrote Another Part of the Forest, a prequel chronicling the roots of the Hubbard family.
The Little Foxes was presented on Philip Morris Playhouse October 10, 1941. The radio adaptation starred Tallulah Bankhead.