Mike Nichols directed a production that opened October 26, 1967, at the Vivian Beaumont Theater in Lincoln Center, then transferred to the Ethel Barrymore Theatre. It ran a total of 100 performances. The cast included Anne Bancroft as Regina, Richard A. Dysart as Horace, Margaret Leighton as Birdie, E.G. Marshall as Oscar, George C. Scott as Benjamin, and Austin Pendleton as Leo. Costume design was by Patricia Zipprodt. In reviewing the production, Time said, "An admirable revival of Lillian Hellman's 1939 play in Lincoln Center demonstrates how securely bricks of character can be sealed together with the mortar of plot. Anne Bancroft, George C. Scott, Richard Dysart and Margaret Leighton are expertly guided by Director Mike Nichols through gilt-edged performances." 
Austin Pendleton directed a production at the Parker Playhouse in Fort Lauderdale for three weeks that transferred to the Kennedy Center in Washington, D.C. for six weeks before opening on Broadway. The production played eight previews, opening May 7, 1981, at the Martin Beck Theatre for 123 performances. The cast included Elizabeth Taylor as Regina, Tom Aldredge as Horace, Dennis Christopher as Leo, Maureen Stapleton as Birdie, and Anthony Zerbe as Benjamin. Florence Klotz was costume designer. In a Time article prior to the Broadway opening, Gerald Clarke reported nearly $1 million worth of ticket sales during the week after advertisements announcing Taylor's appearance appeared in The New York Times. Taylor received nominations for both the Tony Award for Best Performance by a Leading Actress in a Play and the Drama Desk Award for Outstanding Actress in a Play. Tony nominations also went to Pendleton for Best Direction of a Play, Aldredge for Best Featured Actor in a Play, Stapleton for Best Featured Actress in a Play, and the play itself for Best Reproduction.
A 1997 revival, again at the Vivian Beaumont, ran for 27 previews and 57 performances between April 3 and June 15. Directed by Jack O'Brien, the cast included Stockard Channing as Regina, Kenneth Welsh as Horace, Brian Kerwin as Oscar, Brian Murray as Benjamin, and Frances Conroy as Birdie. Murray was nominated for the Tony Award for Best Featured Actor in a Play and won the Drama Desk Award for Outstanding Featured Actor in a Play, and John Lee Beatty was nominated for the Tony Award for Best Scenic Design.
The production was revived at The Shakespeare Theatre of New Jersey, June 3–28, 2009, with Venida Evans, Ron Brice, Deanne Lorette, Brian Dykstra, Fisher Neal, Kathryn Meisle, Einar Gunn, Philip Goodwin, Lindsey Wochley, Bradford Cover, and directed by Matthew Arbour.
Another revival was produced by Cleveland Play House in the 75th anniversary year of the original Broadway production, September 12 - October 5, 2014 in the Allen Theatre (Playhouse Square) in Cleveland, Ohio. The production was directed by Artistic Director Laura Kepley.