Aylmer is a brilliant and recognized scientist and philosopher who drops his focus from his career and experiments to marry the beautiful Georgiana (who is physically perfect except for a small red birthmark in the shape of a hand on her cheek).
As the story progresses, Aylmer becomes unnaturally obsessed with the birthmark on Georgiana's cheek. One night, he dreams of cutting the birthmark out of his wife's cheek (removing it like scraping the skin from an apple) and then, realizing that the birthmark is deeper, continuing all the way to her heart. He does not remember this dream until Georgiana asks about what his sleep-talking meant. When Aylmer remembers the details of his dream, Georgiana declares that she would rather risk her life having the birthmark removed from her cheek than to continue to endure Aylmer's horror and distress that comes upon him when he sees her.
The following day, Aylmer deliberates and then decides to take Georgiana to the apartments where he keeps a laboratory. He glances at Georgiana with the intent to console her but can't help but shudder violently at seeing her imperfection; Aylmer's reaction causes her to faint. When she awakens, he treats her warmly and comforts her with some of his scientific concoctions but when he attempts to take a portrait of her, the image is blurred save for her birthmark revealing the disgust he has of it.
He experiments some more and describes some of the successes to her but as he questions how she is feeling, Georgiana begins to suspect that Aylmer has been experimenting on her the entire time without her knowledge and consent. One day, she follows him into his laboratory, and on seeing her there, Aylmer accuses her of not trusting him and says that having her birthmark in the room will foil his efforts. She professes complete trust in him but demands that he inform her of his experiments. He agrees and reveals that his current experiment is his last attempt to remove the birthmark, and Georgiana vows to take the potion, regardless of any danger it poses to her.
Soon after, Aylmer brings her the potion, which he demonstrates as effective by rejuvenating a diseased plant with a few drops. Protesting that she doesn't need proof to trust her husband, Georgiana drinks the concoction and promptly falls asleep. Aylmer watches and rejoices as the birthmark fades little by little. Once it is nearly gone, Georgiana wakes up to see her image in a mirror, the birthmark almost completely faded. She smiles but then informs Aylmer that she is dying. Once the birthmark fades completely, Georgiana dies.
