- Humphrey Bogart as Philip Marlowe
- Lauren Bacall as Vivian Sternwood Rutledge
- John Ridgely as Eddie Mars
- Martha Vickers as Carmen Sternwood
- Sonia Darrin as Agnes Lowzier (uncredited)[8]
- Dorothy Malone as Acme Bookstore proprietress
- Regis Toomey as Chief Inspector Bernie Ohls
- Peggy Knudsen as Mona Mars
- Charles Waldron as General Sternwood
- Charles D. Brown as Norris, Sternwood's butler
- Bob Steele as Lash Canino
- Elisha Cook, Jr. as Harry Jones
- Louis Jean Heydt as Joe Brody
- Trevor Bardette as Art Huck, gas station owner (uncredited)
- Tommy Rafferty as Carol Lundgren (uncredited)
- Ben Welden as Pete, Mars' henchman (uncredited)
- Tom Fadden as Sidney, Mars' henchman (uncredited)
- Theodore von Eltz as A.G. Geiger (uncredited)
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