Answer
The activation of B cells is takes place in response to the antigenic challenge and the cells that are specific for a particular antigen are proliferated and are differentiated into plasma cells. The plasma cells produce antibodies that effectively bind to the pathogen and eliminate it from the system of an organism.
Work Step by Step
The activation of B-cell is a crucial step for generating an immunological response toward a pathogen. The activation of B cell requires various steps that are listed below:
1. Recognition of invader by B cell: The foreign particle is encountered and recognized by the B cells and it binds to an epitope on an antigen. This antigen is further processed and peptide fragments are presented through MHC (major histocompatibility complex) class II proteins.
2. Stimulation of helper T cell: The helper T cell is stimulated after the presentation of antigen via the MHC–peptide complex on the surface of B cells.
3. Activation of helper T cell: The helper T cell activates the B cell by releasing cytokines of helper T cell.
4. Clonal expansion: The clonal expansion of activated B cells occurs and they differentiate into daughter plasma cells. This eventually produces large quantities of antibodies that further bind to antigens and destroy them
