Answer
$-4$
Work Step by Step
Using the product of the sum and difference of like terms which is given by $(a+b)(a-b)=a^2-b^2,$ the given expression, $
(\sqrt{5}+3)(\sqrt{5}-3)
,$ is equivalent to
\begin{array}{l}\require{cancel}
(\sqrt{5}+3)(\sqrt{5}-3)
\\\\=
(\sqrt{5})^2-(3)^2
\\\\=
5-9
\\\\=
-4
.\end{array}