The novel follows a working-class African-American family living in southern Mississippi in 2005. The family consists of Daddy, his daughter Esch (the narrator), and his sons Randall, Skeetah, and Junior. Their mother died while giving birth to Junior. Skeetah has a close relationship with his dog China, who gives birth to a litter of puppies at the beginning of the novel. Esch finds out she is pregnant by Manny, a friend of the family's who is dating another girl. Skeetah and Manny have an altercation at one of Randall's basketball games, and they agree to resolve it through a dog fight. China prevails over Manny's cousin's dog after a vicious fight.
Soon afterwards, Hurricane Katrina hits. The family is forced into the attic and eventually onto the roof as water begins to flood into their home. As the water continues to rise, they make a desperate bid to swim to another house on a hill, but in the maelstrom China and her puppies are lost. After the end of the storm, the entire town has been leveled, Manny refuses to take responsibility for Esch's baby, and Skeetah still holds out hope that he will find China.
