| Characters | World Premiere | London debut | Broadway debut | HBO Miniseries | Off-Broadway Revival | 2nd Off-Broadway Revival | 1st West End Revival | 1st Broadway Revival |
|---|---|---|---|---|---|---|---|---|
| 1991/1992 | 1993 | 2003 | 2010 | 2017 | 2018 | |||
| Prior Walter | Sean Chapman | Stephen Dillane | Stephen Spinella | Justin Kirk | Christian Borle | Michael Urie | Andrew Garfield | |
| Louis Ironson | Marcus D'Amico | Jason Isaacs | Joe Mantello | Ben Shenkman | Zachary Quinto | Adam Driver | James McArdle | |
| Joe Pitt | Nick Reding | Daniel Craig | David Marshall Grant | Patrick Wilson | Bill Heck | Russell Tovey | Lee Pace | |
| Harper Pitt | Felicity Montagu | Clare Holman | Marcia Gay Harden | Mary-Louise Parker | Zoe Kazan | Keira Keeley | Denise Gough | |
| Roy Cohn | Henry Goodman | David Schofield | Ron Leibman | Al Pacino | Frank Wood | Nathan Lane | ||
| Belize | Joseph Mydell | Jeffrey Wright | Billy Porter | Nathan Stewart-Jarrett | ||||
| The Angel | Nancy Crane | Ellen McLaughlin | Emma Thompson | Robin Weigert | Sofia Jean Gomez | Amanda Lawrence | ||
| Hannah Pitt | Rosemary Martin | Susan Engel | Kathleen Chalfant | Meryl Streep | Robin Bartlett | Lynne McCollough | Susan Brown |
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