In 2003, HBO Films created a miniseries version of the play. Kushner adapted his original text for the screen, and Mike Nichols directed. HBO broadcast the film in various formats: three-hour segments that correspond to "Millennium Approaches" and "Perestroika," as well as one-hour "chapters" that roughly correspond to an act or two of each of these plays. The first three chapters were initially broadcast on December 7, to international acclaim, with the final three chapters following. Angels in America was the most watched made-for-cable movie in 2003 and won both the Golden Globe and Emmy for Best Miniseries.
Kushner made certain changes to his play (especially Part II, "Perestroika") for it to work on screen, but the HBO version is generally a faithful representation of Kushner's original work. Kushner has been quoted as saying that he knew Nichols was the right person to direct the movie when, at their first meeting, Nichols immediately said that he wanted actors to play multiple roles, as had been done in onstage productions.
The lead cast includes Al Pacino, Meryl Streep, Emma Thompson, Jeffrey Wright (repeating his Tony-winning Broadway role), Justin Kirk, Ben Shenkman, Patrick Wilson, and Mary-Louise Parker.
Angels in America – The Opera made its world premiere at the Théâtre du Châtelet in Paris, France, on November 23, 2004. The opera was based on both parts of the Angels in America fantasia, however the script was re-worked and condensed to fit both parts into a two and half hour show. Composer Peter Eötvös explains: "In the opera version, I put less emphasis on the political line than Kushner...I rather focus on the passionate relationships, on the highly dramatic suspense of the wonderful text, on the permanently uncertain state of the visions." A German version of the opera followed suit in mid-2005. In late 2005, PBS announced that they would air a live filmed version of the opera as a part of its Great Performances lineup. The opera made its U.S. debut in June 2006 at the Stanford Calderwood Pavilion in Boston, Massachusetts.
The text of Prior Walter's soliloquy from Scene 5 of Perestroika was set to music by Michael Shaieb for a 2009 festival celebrating Kushner's work at the Guthrie Theater. The work was commissioned by the Twin Cities Gay Men's Chorus, which had commissioned Shaieb's Through A Glass, Darkly in 2008. The work premiered at the Guthrie in April 2009.