- The book was adapted into a 1945 film directed by Elia Kazan, starring James Dunn, Dorothy McGuire, Joan Blondell, and Peggy Ann Garner, who won a Special Academy Award for Outstanding Child Actress of 1945. James Dunn won an Academy Award for Best Supporting Actor in the film.
- George Abbott produced and directed the story as a 1951 Broadway musical, collaborating with the author on the book, and with music by Arthur Schwartz and choreography by Herbert Ross. The show starred Shirley Booth, Marcia van Dyke, and twelve-year-old Nomi Mitty played Francie. It ran for 267 performances.
- Yet another adaptation was a 1974 "made for television" movie starring Cliff Robertson and Pamelyn Ferdin, which was based on the film's screenplay. This TV movie was a pilot for a weekly series drama which was never produced.
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