- Matt Damon as Tom Ripley
- Gwyneth Paltrow as Marge Sherwood
- Jude Law as Dickie Greenleaf
- Cate Blanchett as Meredith Logue
- Philip Seymour Hoffman as Freddie Miles
- Jack Davenport as Peter Smith-Kingsley
- James Rebhorn as Herbert Greenleaf
- Sergio Rubini as Inspector Roverini
- Philip Baker Hall as Alvin MacCarron
- Celia Weston as Aunt Joan
- Rosario Fiorello as Fausto
- Stefania Rocca as Silvana
- Ivano Marescotti as Colonnello Verrecchia
- Lisa Eichhorn as Emily Greenleaf
- Silvana Bosi as Ermelinda
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