Lord Strange's Men staged a play that the records call Jeronimo on 23 February 1592 at The Rose for Philip Henslowe, and repeated it sixteen times to 22 January 1593; it was their big hit of the season. It is unlikely, however, that the performance in February of 1592 was the play's first performance, as Henslowe did not mark it as 'ne' (new). It is unclear whether Jeronimo was The Spanish Tragedy, or The First Part of Hieronimo (printed in 1604), the anonymous "prequel" to Kyd's play, or perhaps either on different days.
The Admiral's Men revived Kyd's original on 7 January 1597, and performed it twelve times to 19 July; they staged another performance conjointly with Pembroke's Men on 11 October the same year. The records of Philip Henslowe suggest that the play was on stage again in 1601 and 1602. English actors performed the play on tour in Germany (1601), and both German and Dutch adaptations were made.