Modern adaptations of the play have been written by Tony Harrison and Liz Lochhead. Lochhead's version is set in the early years of the Scottish Parliament and satirises Scottish Labour's relationship with the media. Originally written in 1973, Harrison's version was updated and revived at the Bristol Old Vic in 2010.
In 1999, Uma Thurman and Roger Rees starred in Classic Stage Company's contemporary version by Martin Crimp directed by Barry Edelstein.
Robert Cohen's 2006 translation into heroic couplets was praised by the Los Angeles Times as "highly entertaining... with a contemporary flavor full of colloquial yet literate pungency." Professor Cohen's version has been popular in productions staged by his former students, and it is the version staged by Keith Fowler in 2011 for UC Irvine's celebration of Cohen's fifty years at the university.
The Grouch, a more modern verse version of The Misanthrope by Ranjit Bolt was first performed at West Yorkshire Playhouse in February 2008. It is set in contemporary London, and most of the characters' names are recognisably linked to Molière's: in the sequence of the above cast list they are Alan, Celia, Phil, Eileen, Orville, Fay (Arsinoe), Lord Arne, Chris, and manservant Bates. Martin Crimp's adaptation, starring Damian Lewis and Keira Knightley, opened at the Comedy Theatre, London in December 2009. Another adaptation by Roger McGough was premiered by the English Touring Theatre at the Liverpool Playhouse in February 2013 prior to a national tour – this adaptation is largely in verse, but has Alceste speaking in prose. In June 2014, Andy Clark, Rosalind Sydney and Helen MacKay appeared in a three-handed 50-minute Classic Cuts version of The Misanthrope, written in rhyming couplets by Frances Poet, set and performed in the basement theatre of Glasgow's Òran Mór [Gaelic for 'great melody of life], the former Kelvinside Parish Church, where the city's lunchtime theatre, A Play, A Pie and a Pint, celebrated its tenth anniversary a few days after the death of its founder David MacLennan . Joyce McMillan in The Scotsman noted 'the sheer, sharp-edged wit of Poet’s rhyming text, which pays perfect homage to the original, while diving boldly into the new world of fall-outs and friendships conducted on social media.'