The House of Blue Leaves, directed by Mel Shapiro, opened on February 10, 1971 Off-Broadway at the Truck and Warehouse Theatre, where it ran for 337 performances. The cast included Frank Converse, Harold Gould, Katherine Helmond, William Atherton, and Anne Meara.
A 1986 revival directed by Jerry Zaks was staged Off-Broadway Mitzi E. Newhouse Theater at Lincoln Center for the Performing Arts and then transferred to the Vivian Beaumont Theater, where it played five months before transferring again to the Plymouth Theatre, for a total run of 398 performances. The opening night cast included Swoosie Kurtz, John Mahoney, Stockard Channing, Danny Aiello, Ben Stiller (in his stage debut), and Julie Hagerty. Christine Baranski and Patricia Clarkson joined the production later in the run. It won the Drama Desk Award for Outstanding Revival. It was also nominated for the Tony Award for Best Play.
A 2011 Broadway revival was staged by David Cromer at the Walter Kerr Theatre. Starring Ben Stiller (Artie), Edie Falco (Bananas) and Jennifer Jason Leigh (Bunny), the production began previews on April 4, with an opening date on April 15 for a limited 16-week engagement.