The score to The Fly was composed and conducted by Howard Shore, and performed by the London Philharmonic Orchestra. It was released on record, cassette, and Compact Disc (with three additional tracks exclusively included on the latter) by Varèse Sarabande, and in 2005, it was remastered and reissued on a two-disc set with Christopher Young's album for The Fly II.
Titles in bold are exclusive to the CD release. The soundtrack presents the music out of order from the movie's presentation.
- Main Title 1:54
- Plasma Pool 1:54
- The Last Visit 2:25
- Stathis Enters 2:20
- The Phone Call 2:07
- Seth Goes Through 2:02
- Ronnie Comes Back 0:55
- The Jump 1:21
- Seth and the Fly 2:21
- Particle Magazine 1:02
- The Armwrestle 0:51
- Brundlefly 1:43
- Ronnie's Visit 0:35
- The Street 0:43
- The Stairs 1:25
- The Fingernails 2:35
- Baboon Teleportation 0:58
- The Creature 2:08
- Steak Montage 0:59
- The Maggot/Fly Graphic 1:37
- Success With Baboon 0:58
- The Ultimate Family 1:59
- The Finale 2:51