- Robin Williams as Henry "Parry" Sagan
- Jeff Bridges as Jack Lucas
- Mercedes Ruehl as Anne Napolitano
- Amanda Plummer as Lydia Sinclair
- Christian Clemenson as Edwin Malnek
- Michael Jeter as Homeless Cabaret Singer
- David Hyde Pierce as Lou Rosen
- Lara Harris as Sondra
- Harry Shearer as Ben Starr
- William Jay Marshall as Jamaican Bum
- Chris Howell as the Red Knight
- Kathy Najimy as Crazed Video Customer
- John de Lancie as TV Executive
- Tom Waits as Disabled Veteran
- Melinda Culea as Sitcom Wife
- Paul Michael Lombardi as Radio Engineer
- Ted Ross as Limo Bum
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