Answer
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Sickle cell anemia is a genetic disease caused by a point mutation in the beta globin chain of hemoglobin replacing the amino acid Glutamic acid with Val at the 6th position of the beta chain. Glutamic acid is a polar, acidic amino acid and can get exposed to the hydrophilic water interface in the cell. On the other hand, Valine is a non-polar amino acid that has to be buried inside the hydrophobic region. This mutation renders the protein misfolded and non-functional. This mutation (Glu6 to Val) favors a hydrophobic interaction between each strand.
