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Dinitrolphenol ( DNP ) and Weight Loss
- DNP was one of the first anti-obesity therapy in the
1940 s.
- it was shown to cause weight loss by increasing the
rate of oxidation by uncoupling oxidation from the
formation of high energy phosphate
( = phospharylation )
leads to generation of heat, leading to high Metabolic
Rate and increased fat metabolism.
- in presence of DNP, electron transport continue ,
even at a higher rate, but ATP production is
decreased, the energy that should have been
converted to chemical energy in the form of ATP
is then released as excess heat ( = DNP uncouples
the Chemiosomatic Machinery ).
- DNP in a dose of 3-5 mg/kg. increases the Metabolic
Rate more than 20% for 24-48 hours.
if given chronically, a 50% elevation can be
maintained.
- in the past, it was used for the treatment of obesity
but serious side effects lead to its withdrawal from
use. ( = death of patients )
