Answer
$x^4y^4-10x^2y^2+25$
Work Step by Step
Using $(a\pm b)^2=a^2\pm2ab+b^2$ or the square of a binomial, the square of the given expression, $
(x^2y^2-5)^2
,$ is
\begin{array}{l}\require{cancel}
(x^2y^2)^2-2(x^2y^2)(5)+(5)^2
\\\\=
x^4y^4-10x^2y^2+25
.\end{array}