A film adaptation of the book, also called Slaughterhouse-Five, was made in 1972. Although critically praised, the film was a box office flop. It won the Prix du Jury at the 1972 Cannes Film Festival, as well as a Hugo Award and Saturn Award. Vonnegut commended the film greatly. Guillermo del Toro has confirmed his intention to remake the 1972 film, originally hoping to release it in early 2011. Due to his involvement with The Hobbit, the date of release for a film adaptation was pushed back. Although Guillermo del Toro has since dropped out of involvement with The Hobbit, the possibility of a new adaptation remains in question, since it is not among several projects Del Toro is said to be working on as of summer 2013.
In 1989, a theatrical adaption premiered at The Everyman Theatre, Liverpool, in the UK. This was the first time the novel had been presented onstage. It was adapted by Vince Foxall, and directed by Paddy Cunneen. In 1996, a theatrical adaptation of the novel was premiered at the Steppenwolf Theatre Company in Chicago, IL. The adaptation was written and directed by Eric Simonson and included actors Rick Snyder, Robert Breuler and Deanna Dunagan. The play has been performed in several other theaters, including a January 2008 New York premiere production, at the Godlight Theatre Company. The operatic adaptation by Hans-Jürgen von Bose, premiered in July 1996 at the Bavarian State Opera in Munich. Billy Pilgrim II was sung by Uwe Schonbeck.
In September 2009 BBC Radio 3 broadcast a feature length radio drama based on the book, which was dramatised by Dave Sheasby, which starred Andrew Scott as Billy Pilgrim and was scored by the group 65daysofstatic.
From June 9 to July 3, 2015, Book-It Repertory Theatre in Seattle, Washington (USA) presented an adaptation of the book by Josh Aaseng, who also directed. It starred Robert Bergin, Erik Grafton, and Todd Jefferson Moore as Billy Pilgrim (at three different ages). As is Book-It's practice, every word in the production is taken directly from the text of the book.