The film was shot entirely at Paramount studios, which included an enormous indoor set to replicate a Greenwich Village courtyard. Set designers Hal Pereira and Joseph MacMillan Johnson spent six weeks building the extremely detailed and complex set, which ended up being the largest of its kind at Paramount. One of the unique features of the set was its massive drainage system, constructed in order to accommodate the rain sequence in the film. They also built the set around a highly-nuanced lighting system which was able to create natural-looking lighting effects for both the day and night scenes. Even though the address given in the film is 125 W. Ninth Street in New York's Greenwich Village, the set was actually based on a real courtyard located at 125 Christopher Street.
In addition to the meticulous care and detail put into the set, there was also careful attention given to sound, including the use of natural sounds and music that would drift across the courtyard and into Jefferies' apartment. At one point, the voice of Bing Crosby can be heard singing "To See You Is to Love You", originally from the 1952 Paramount film Road to Bali. Also heard on the soundtrack are versions of songs popularized earlier in the decade by Nat King Cole ("Mona Lisa", 1950) and Dean Martin ("That's Amore", 1952), along with segments from Leonard Bernstein's score for Jerome Robbins' ballet Fancy Free (1944), Richard Rodgers' song "Lover" (1932), and "M'appari tutt'amor" from Friedrich von Flotow's opera Martha (1844), most borrowed from Paramount's music publisher, Famous Music.
Hitchcock used costume designer Edith Head on all of his Paramount films.
Although veteran Hollywood composer Franz Waxman is credited with the score for the film, his contributions were limited to the opening and closing titles and the piano tune ("Lisa") written by one of the neighbors, a composer (Ross Bagdasarian), during the film. This was Waxman's final score for Hitchcock. The director used primarily "diegetic" sounds—sounds arising from the normal life of the characters—throughout the film.