- Oliver Twist – an orphan child whose mother died at his birth
- Mr Bumble – a beadle in the parish workhouse where Oliver was born
- Mrs Mann – the self-centred and greedy superintendent where the infant Oliver is placed until age 9
- Mr Sowerberry – an undertaker who took Oliver as apprentice
- Mrs Sowerberry – Mr Sowerberry's wife
- Noah Claypole – a cowardly bully, Sowerberry's apprentice
- Charlotte – the Sowerberrys' maid, lover of Noah
- Mr Gamfield – a chimney sweep in the town where Oliver was born
- Mr Brownlow – a kind gentleman who takes Oliver in, his first benefactor
- Mr Grimwig – a friend of Mr Brownlow
- Mrs Bedwin – Mr Brownlow's housekeeper
- Rose Maylie – Oliver's second benefactor, later found to be his aunt
- Mrs Lindsay Maylie – Harry Maylie's mother, Rose Maylie's adoptive aunt
- Harry Maylie – Mrs Maylie's son
- Mr Losberne – Mrs Maylie's family doctor
- Mr Giles – Mrs Maylie's butler
- Mr Brittles – Mrs Maylie's handyman
- Duff and Blathers – two incompetent policemen
- Fagin – fence and boss of a criminal gang of young boys and girls
- Bill Sikes – a professional burglar
- Bull's Eye – Bill Sikes's vicious dog
- The Artful Dodger – Fagin's most adept pickpocket
- Charley Bates – a pickpocket in Fagin's gang
- Toby Crackit – an associate of Fagin and Sikes, a house-breaker
- Nancy – one of Fagin's gang, now living with Bill Sikes
- Bet – a girl in Fagin's gang, sometime friend to Nancy
- Barney – a criminal cohort of Fagin
- Agnes Fleming – Oliver's mother
- Mr Leeford – father of Oliver and Monks
- Old Sally – a nurse who attended Oliver's birth
- Mrs Corney – matron for the women's workhouse
- Monks – a sickly criminal, an associate of Fagin's, and long-lost half-brother of Oliver
- Monks's mother – an heiress who did not love her husband
- Mr Fang – a magistrate
- Tom Chitling – one of Fagin's gang members, returned from abroad at the time of the murder
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