- My Sister's Keeper, 1961 novel by Ronald Verlin Cassill
- My Sisters' Keeper, 1970 novel by L. P. Hartley
- My Sister's Keeper, 1979 novel by Rachel Lindsay (Roberta Leigh), also named Janey Scott
- My Sister's Keeper (novel), 2004 novel by Jodi Picoult
- My Sister's Keeper, 2005 novel of the Journey of the Sacred King series by Janrae Frank
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