- McTeague (also known as Life's Whirlpool) starring Holbrook Blinn and Fania Marinoff was released in 1916. It is considered a lost film.
- Greed, Erich von Stroheim's film version of McTeague, was made in 1924. In its original form, it lasted approximately eight hours but was cut drastically by the studio, MGM, and most of the excised footage has been lost. The first name of "Mac" McTeague in Greed is John.
- Karen Kearns produced a radio drama version of McTeague in 1989, under a fellowship for the Corporation for Public Broadcasting. The program features Stacy Keach, Carol Kane, Hector Elizondo, JoBeth Williams, Michael York, Katherine Helmond, Ed Asner, Joe Spano, and many other well-known actors.
- McTeague was the basis of an opera of the same name by composer William Bolcom and librettist Arnold Weinstein, which premiered on October 31, 1992.
- Greedy is a 1994 American comedy film directed by Jonathan Lynn and written by Lowell Ganz and Babaloo Mandel. The film stars Michael J. Fox, Kirk Douglas, and Nancy Travis, with Phil Hartman, Ed Begley Jr., Olivia d'Abo, Colleen Camp, and Bob Balaban appearing in supporting roles. The original music score was composed by Randy Edelman. It is a very loose adaptation of McTeague.
- Slow Burn is a 2000 drama film directed by Christian Ford and starring Minnie Driver, James Spader, Stuart Wilson, and Josh Brolin. It is a very loose adaptation of McTeague.
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