The novel continues the story of some of the same characters in the wake of the same biological catastrophe depicted in Atwood's earlier novels in the trilogy. The narrative starts with Ren and Toby (protagonists in The Year of the Flood) rescuing another survivor (Amanda Payne) from two criminals, who had been previously emotionally hardened by a colosseum-style game called Painball. Ren and Toby meet up with Jimmy, the protagonist from Oryx and Crake. These characters reunite with other survivors, develop a camp and start to rebuild civilization with the Crakers, all while the vengeful criminals (Painballers) stalk them.
Similarly to the previous two books, the narrative switches periodically into the past. After Zeb and Toby become lovers, he tells her about his previous career. Zeb and Adam One (from The Year of the Flood) grew up as half-brothers. Their father, a preacher ("The Rev"), advocated a corporate-friendly message that espoused petroleum and shunned environmentalism. Disgusted by his father's ethics and hypocrisy, Zeb hacks into his father's accounts and empties them. Knowing their father's political influence, Zeb and Adam leave home, take on different identities and separate in order to avoid detection. Ultimately, Zeb and Adam re-unite and work together in building God's Gardeners, the central organization in The Year of the Flood.
