A number of films have been based on the lengthy book, making various cuts, compressions, and changes. The American adaptations include:
- a 1912 version starring James Cruze,
- The Last of the Mohicans (1920), starring Wallace Beery;
- The Last of the Mohicans (1932), a serial version starring Harry Carey;
- The Last of the Mohicans (1936) starring Randolph Scott and Bruce Cabot;
- Last of the Redmen (1947) starring Jon Hall and Michael O'Shea;
- The Iroquois Trail (1950) starring George Montgomery
- Last of the Mohicans (1963) starring Jack Taylor. Jose Marco, Luis Induni and Daniel Martin;
- The Last of the Mohicans (1992), starring Daniel Day-Lewis.
The 1920 film has been deemed "culturally significant" by the Library of Congress and selected for preservation in the United States National Film Registry. According to the director Michael Mann, his 1992 version was based more on the 1936 film version. Mann believes Cooper's novel is "not a very good book," taking issue with Cooper's sympathy for the Euro-Americans and their seizure of the American Indians' domain.
In Germany, Der Letzte der Mohikaner, with Béla Lugosi as Chingachgook, was the second part of the two-part Lederstrumpf film released in 1920. Der letzte Mohikaner directed by Harald Reinl was a 1965 West German/Italian/Spanish co-production setting elements of the story in the post American Civil War era. Based on the same series of the novels, Chingachgook die Grosse Schlange (Chingachgook the Great Serpent), starring Gojko Mitic as Chingachgook, appeared in East Germany in 1967, and became popular throughout the Eastern Bloc.
- The Last of the Mohicans was adapted for radio in two one-hour episodes directed by Michael Fox and broadcast on BBC Radio 4 in 1995 (subsequently on BBC Radio 7), with Michael Fiest, Philip Franks, Helen McCrory and Naomi Radcliffe.
- There was a Canadian TV series, Hawkeye and the Last of the Mohicans in 1957 with John Hart as Hawkeye and Lon Chaney, Jr. as Chingachgook.
- The BBC made a TV serial of the book in 1971, with Philip Madoc as Magua, Kenneth Ives as Hawkeye and John Abineri as Chingachgook, which some critics believe to be the most faithful and the best adaptation.
- In a 1977 American made-for-TV movie, Steve Forrest starred as Hawkeye with Ned Romero as Chingachgook and Don Shanks as Uncas.
In 1977, Lake George Opera presented an opera version The Last of the Mohicans by composer Alva Henderson.
Classic Comics #4, The Last of the Mohicans, first published 1942.
Marvel Comics has published two versions of the story: in 1976 a one-issue version as part of their Marvel Classics Comics series (issue #13). In 2007, they published a six-issue mini-series to start off the new Marvel Illustrated series.
Famed manga artist Shigeru Sugiura wrote and illustrated a very loose manga adaptation of the story in 1952-3 (remade in 1973-4). This adaptation is heavily influenced by American movies and western comics and is filled with absurd humor and anachronistic jokes. An English translation of Sugiura's 1973-4 version including a lengthy essay on Sugiura's artistic influences was published in the United States in 2013.