One of the earliest cultural references to the play came in Shakespeare's own Hamlet. Prince Hamlet asks Polonius about his career as a thespian at university, Polonius replies "I did enact Julius Caesar. I was killed i' th' Capitol. Brutus killed me." This is a likely meta-reference, as Richard Burbage is generally accepted to have played leading men Brutus and Hamlet, and the older John Heminges to have played Caesar and Polonius.
In 1851 the German composer Robert Schumann wrote a concert overture Julius Caesar, inspired by Shakespeare's play. Other musical settings include those by Giovanni Bononcini, Hans von Bülow, Felix Draeseke, Josef Bohuslav Foerster, John Ireland, John Foulds, Gian Francesco Malipiero, Manfred Gurlitt, Darius Milhaud and Mario Castelnuovo-Tedesco.
The Canadian comedy duo Wayne and Shuster parodied Julius Caesar in their 1958 sketch Rinse the Blood off My Toga. Flavius Maximus, Private Roman Eye, is hired by Brutus to investigate the death of Caesar. The police procedural combines Shakespeare, Dragnet, and vaudeville jokes and was first broadcast on The Ed Sullivan Show.
The 1960 film An Honourable Murder is a modern reworking of the play.
In 1973 the BBC made a television play Heil Caesar, written by John Griffith Bowen. This was an adaptation of the play put into a modern setting in an unnamed country, with references to recent events in a few countries. It was intended as an introduction to Shakespeare's play for schoolchildren, but it proved good enough to be shown on adult television, and a stage version was later produced.
In 1984 the Riverside Shakespeare Company of New York City produced a modern dress Julius Caesar set in contemporary Washington, called simply CAESAR!, starring Harold Scott as Brutus, Herman Petras as Caesar, Marya Lowry as Portia, Robert Walsh as Antony, and Michael Cook as Cassius, directed by W. Stuart McDowell at The Shakespeare Center.
In 2006, Chris Taylor from the Australian comedy team The Chaser wrote a comedy musical called Dead Caesar which was shown at the Sydney Theatre Company in Sydney.
The line "The Evil That Men Do", from the speech made by Mark Antony following Caesar's death ("The evil that men do lives after them; The good is oft interred with their bones.") has had many references in media, including the titles of ...
- An Iron Maiden song
- A politically oriented film directed by J. Lee Thompson in 1984
- A Buffy the Vampire Slayer novel.
Shakespeare's use of this line may have been influenced by the Greek playwright Euripides (c. 480-406 BC), who wrote, "When good men die their goodness does not perish, but lives though they are gone. As for the bad, all that was theirs dies and is buried with them."
The 2009 movie Me and Orson Welles, based on a book of the same name by Robert Kaplow, is a fictional story centred around Orson Welles' famous 1937 production of Julius Caesar at the Mercury Theatre. British actor Christian McKay is cast as Welles, and costars with Zac Efron and Claire Danes.
The 2012 Italian drama film Caesar Must Die (Italian: Cesare deve morire), directed by Paolo and Vittorio Taviani, follows convicts in their rehearsals ahead of a prison performance of Julius Caesar.
In the Ray Bradbury book Fahrenheit 451, some of the character Beatty's last words are "There is no terror, Cassius, in your threats, for I am armed so strong in honesty that they pass me as an idle wind, which I respect not!"
The play's line "the fault, dear Brutus, lies not in our stars, but in ourselves", spoken by Cassius in Act I, scene 2, has entered popular culture. The line gave its name to the J.M. Barrie play Dear Brutus, and also gave its name to the bestselling young adult novel The Fault in Our Stars by John Green and its film adaptation. The same line was quoted in Edward R. Murrow's epilogue of his famous 1954 See It Now documentary broadcast concerning Senator Joseph R. McCarthy. This speech and the line were recreated in the 2005 film Good Night, and Good Luck. It was also quoted by George Clooney's character in the Coen brothers film Intolerable Cruelty.
The line "And therefore think him as a serpent's egg/Which hatch'd, would, as his kind grow mischievous; And kill him in the shell." spoken by Brutus in Act II, scene 1, is referenced to in the Dead Kennedys song, "California Über Alles".