- Ishmael (Moby-Dick), the narrator in the novel Moby-Dick by Herman Melville
- Ishmael, a "mad" character with apparent mystical powers in Ingmar Bergman's film Fanny and Alexander
- Ishmael, the wizard who imprisoned the goblins in Goblins in the Castle by Bruce Coville
- Ishmael, the main protagonist in The Haj, a 1984 novel by Leon Uris
- Ishmael (character), the name of two fictional characters in DC Comics
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