- Tom Cruise as Dr. William "Bill" Harford
- Nicole Kidman as Alice Harford
- Sydney Pollack as Victor Ziegler
- Todd Field as Nick Nightingale
- Marie Richardson as Marion Nathanson
- Sky du Mont as Sandor Szavost
- Rade Šerbedžija as Mr. Milich
- Thomas Gibson as Carl Thomas
- Vinessa Shaw as Domino
- Fay Masterson as Sally
- Alan Cumming as Hotel Desk Clerk
- Leelee Sobieski as Milich's daughter
- Leon Vitali as Red Cloak
- Julienne Davis as Amanda "Mandy" Curran
- Madison Eginton as Helena Harford
- Abigail Good as Mysterious Woman
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