Extremely Loud & Incredibly Close received the following accolades:
- New York Public Library's "Books to Remember" list
- International Dublin Literary Award Shortlist (2007)
- The Morning News Tournament of Books (Quarterfinalist, 2006)
- The New York Times Bestseller (Fiction, 2005)
- Libraires du Québec (Lauréat Roman hors Québec, 2007)
- ALA Outstanding Books for the College Bound (Literature & Language Arts, 2009)
- ALA Notable Books for Adults (2006)
- Village Voice 25 Favorite Books (2005)
- V&A Illustration Award (2005)
Despite the above, the book has frequently been challenged. According to the American Library Association, it was one of the top one hundred banned and challenged books between 2010 and 2019.[13]