Death and the Maiden had a reading at the Institute for Contemporary Art in London on 30 November 1990:
- Paulina — Penelope Wilton
- Gerardo — Michael Maloney
- Roberto — Jonathan Hyde
- Directed by Peter James
A workshop production was staged and opened in Santiago, Chile, on 10 March 1991:
- Paulina — Maria Elena Duvauchelle
- Gerardo — Hugo Medina
- Roberto — Tito Bustamante
- Directed by Ana Reeves
Death and the Maiden had its world premiere at The Royal Court Upstairs on 9 July 1991:
- Paulina — Juliet Stevenson
- Gerardo — Bill Paterson
- Roberto — Michael Byrne
- Directed by Lindsay Posner
With the same cast and director, it transferred to the Mainstage at The Royal Court on 4 November 1991.
The American Broadway premiere of Death and the Maiden opened at the Brooks Atkinson Theatre on 17 March 1992, produced by Roger Berlind, Gladys Nederlander and Frederick Zollo, in association with Thom Mount and Bonnie Timmermann:
- Paulina — Glenn Close
- Gerardo — Richard Dreyfuss
- Roberto — Gene Hackman
- Directed by Mike Nichols
Indian premiere of Death and the Maiden (in Hindi) opened at India Habitat Centre New Delhi on 17 February 2002,produced by Asmita Theatre, translation by Shalini Vatsa.
Death and the Maiden returns to London's West End 20 years since it first premiered at the Royal Court Theatre. The much awaited return was in 2011 at the Harold Pinter Theatre.
- Paulina – Thandie Newton
- Gerardo – Tom Goodman-Hill
- Roberto – Anthony Calf
- Directed by Jeremy Herrin
A particular version of this play was held in 2010 in Haifa, directed by Juliano Mer Khamis (who was assassinated few months later). The two main characters were played by Clara Khoury and Saleh Bakri.
in 2015 "Death and the Maiden" is being staged as a co-production between Melbourne Theatre Company (18 July-22 August) and the Sydney Theatre Company (2 September-17 October). Susie Porter (Puberty Blues (TV series)) to play Paulina with Eugene Gilfedder (The Effect) as the man whose voice might be his undoing.