The novel has been adapted into various media including opera, film, television, ballet, and radio drama. The first film adaptation was released in 1911 but has not survived.
- 1911: Anna Karenine (1911 film), a Russian adaptation directed by Maurice André Maître.
- 1914: Anna Karenina (1914 film), a Russian adaptation directed by Vladimir Gardin
- 1915: Anna Karenina (1915 film), an American version starring Danish actress Betty Nansen
- 1927: Love (1927 film), an American version, starring Greta Garbo and directed by Edmund Goulding. This version featured significant changes from the novel and had two different endings, with a happy one for American audiences
- 1935: Anna Karenina (1935 film), starring Greta Garbo and Fredric March; directed by Clarence Brown
- 1948: Anna Karenina (1948 film) starring Vivien Leigh and Ralph Richardson; directed by Julien Duvivier
- 1953: Anna Karenina (1953 film), a Russian version directed by Tatyana Lukashevich
- 1960: Nahr al-Hob (River of Love), an Egyptian movie directed by Ezzel Dine Zulficar
- 1967: Anna Karenina (1967 film), a Russian version directed by Alexander Zarkhi
- 1977: Anna Karenina, a 1977 ten-episode BBC series, directed by Basil Coleman and starred Nicola Pagett, Eric Porter and Stuart Wilson.
- 1975/1979: Anna Karenina (1975 film), film of the Bolshoi Ballet production, directed by Margarita Pilikhina, first released in Finland in 1976. U.S. release in 1979
- 1985: Anna Karenina (1985 film), a TV Movie starring Jacqueline Bisset and Christopher Reeve, directed by Simon Langton
- 1997: Anna Karenina (1997 film), the first American version filmed entirely in Russia, directed by Bernard Rose and starring Sophie Marceau and Sean Bean
- 2000: Anna Karenina (2000 TV mini-series), a British version by David Blair and starring Helen McCrory and Kevin McKidd
- 2012: Anna Karenina (2012 film), a British version by Joe Wright from a screenplay by Tom Stoppard, starring Keira Knightley and Jude Law
- 2013: Anna Karenina (2013 film), an English-language Italian/French/Spanish/German/Lithuanian TV co-production by Christian Duguay and starring Vittoria Puccini, Benjamin Sadler and Santiago Cabrera. Alternatively presented as a two-part mini-series or a single 3 hours and 15 minutes film.
In February - March 2012 Myriad Productions staged their original adaptation (by Connie Stephens) of Anna Karenina at Barons Court Theatre with a cast of six actors (Katie Charles, James Edwards, James Kingdon, Jon Marx, Lynsey Mcquaid and Joanna O'Connor).
1904-1905: Anna Karenina by Italian composer Edoardo Granelli, composed in years 1904-1905. 1905: Anna Karenina by Italian composer Salvatore Sassano on libretto by Antonio Menotti. Opera won a prize at the contest of the Institute for the Advancement of Music, Naples and was premièred by Mercadante Theater in Naples in 1905. 1914: Anna Karénine by French composer Edmond Malherbe, unperformed. 1914: Karenina Anna by Hungarian composer Jenő Hubay on libretto by Sándor Góth and Andor Gábor based on 1907 Edmond Guiraud's French dramatical adaptation. Premièred in 1923. 1924: Anna Karenina by Italian verismo composer Igino Robbiani on libretto by Arturo Rosatto, premièred 1924 at the Teatro Costanzi in Rome. 1930: Anna Karenina, op. 18 by Czech composer Stanislav Goldbach on libretto by Dalibor Chalupa, composed 1927-1930. 1970: Anna Karenina by Ukrainian composer Yuly Sergeyevich Meytus. 1978: Anna Karenina by British composer Iain Hamilton on his own libretto, premièred by ENO at the London Coliseum in 1981. 2007: Anna Karenina, an American opera with music by David Carlson on a libretto by Colin Graham which premiered in 2007 at Florida Grand Opera. Second version with an added scene on text by Mark Streshinsky was premièred in 2010 by Opera San Jose.
- 1949: The MGM Theater of the Air, starring Marlene Dietrich and directed by Marx Loeb.