The fictional Hubbards in the play are reputedly drawn from Lillian Hellman's Marx relatives. Hellman's mother was Julia Newhouse of Demopolis, Alabama. Julia Newhouse's parents were Leonard Newhouse, a Demopolis wholesale liquor dealer, and Sophie Marx, of a successful Demopolis banking family. According to Hellman, Sophie Marx Newhouse never missed an opportunity to belittle and mock her father for his poor business sense in front of her and her mother. The discord between the Marx and Hellman families was to later serve as the inspiration for the play.[2][3][4]
The title "The Little Foxes" was suggested by Dorothy Parker.
In 1946, Hellman wrote Another Part of the Forest, a prequel chronicling the roots of the Hubbard family.