Some series have featured adaptations of all the stories in The Case-Book of Sherlock Holmes, including the radio series The Adventures of Sherlock Holmes (1930–1936)[18] and the later radio series The New Adventures of Sherlock Holmes (1939–1950).[19] All but two of the stories in the collection were dramatised for radio as part of the BBC Sherlock Holmes 1952–1969 radio series.
The stories in the collection, except "The Blanched Soldier", "The Lion's Mane", and "The Retired Colourman", were adapted into episodes of the Granada television series (1984–1994). "The Mazarin Stone" and "The Three Garridebs" were combined for one episode, and elements of "The Veiled Lodger" were incorporated into the Granada adaptation of "The Noble Bachelor".[20] The Case-Book of Sherlock Holmes was adapted for BBC Radio 4 in 1994–1995 as part of the Sherlock Holmes 1989–1998 radio series.[21] All the stories in the collection were adapted as episodes of the radio series The Classic Adventures of Sherlock Holmes (2005–2016).[22] Other adaptations of stories within the collection have also been produced.