- James Stewart as L. B. "Jeff" Jefferies
- Grace Kelly as Lisa Fremont
- Wendell Corey as NYPD Det. Lt. Thomas "Tom" J. Doyle
- Thelma Ritter as Stella
- Raymond Burr as Lars Thorwald
- Judith Evelyn as Miss Lonelyhearts
- Ross Bagdasarian as the songwriter
- Georgine Darcy as Miss Torso
- Sara Berner and Frank Cady as the couple living above the Thorwalds, with their dog
- Jesslyn Fax as "Miss Hearing Aid"[7]
- Rand Harper and Havis Davenport as newlyweds[7]
- Irene Winston as Mrs. Anna Thorwald[7]
Uncredited
- Harry Landers as young man guest of Miss Lonelyhearts[7]
- Ralph Smiles as Carl, the waiter[7]
- Fred Graham as detective[7]
- Eddie Parker as detective[7]
- Anthony Warde as detective[7]
- Kathryn Grant as Girl at Songwriter's Party[7]
- Marla English as Girl at Songwriter's Party[7]
- Bess Flowers as Woman at Songwriter's Party with Poodle[7]
- Benny Bartlett as Stanley, Miss Torso's returning boyfriend[7]
- Dick Simmons as Man with Miss Torso[7]
Cast notes
- Director Alfred Hitchcock makes his traditional cameo appearance in the songwriter's apartment, where he is seen winding a clock.[7]