Flowers for Algernon has been adapted many times for different media including stage, screen, and radio. These adaptations include:
- A 1961 episode of the television drama The United States Steel Hour, "The Two Worlds of Charlie Gordon", starring Cliff Robertson.[42][43]
- A 1968 film, Charly, also starring Cliff Robertson, for which he won the Academy Award for Best Actor.[42][44]
- A 1975 stage play, Entaha El-Dars Ya Ghabi (The Lesson Is Over, Stupid) by Egyptian actor Mohamed Sobhi.
- A 1969 stage play, Flowers for Algernon by David Rogers.[42][45]
- A 1978 stage musical, Charlie and Algernon by David Rogers and Charles Strouse.[42][46][47]
- A 1979 rock opera, A Curious Feeling by Tony Banks.[48]
- A 1991 radio play, Flowers for Algernon, for BBC Radio 4 starring Tom Courtenay.[49]
- A 1991 episode of the television series Star Trek: The Next Generation, "The Nth Degree".[50]
- A 2000 television film, Flowers for Algernon, starring Matthew Modine.
- A 2001 episode of the television series The Invisible Man, "Flowers for Hobbes".
- A 2001 Spider-Man comic story, "Flowers for Rhino", by Peter Milligan and Duncan Fregredo.
- A 2002 Japanese drama, Algernon ni Hanataba o for Fuji Television, starring Yūsuke Santamaria.
- A 2005 episode of the television series SpongeBob SquarePants, "Patrick SmartPants".
- A 2006 French television film, Des fleurs pour Algernon.
- A 2013 episode of the television series It's Always Sunny in Philadelphia, "Flowers for Charlie".[51]
- A 2013 episode of the television series The League, "Flowers for Taco".
- A 2015 Japanese drama, Algernon ni Hanataba o for Tokyo Broadcasting System, starring Yamashita Tomohisa and Chiaki Kuriyama.
- A 2018 video game, NieR: Automata, titles its "A" ending Flowers for Machines.
- A 2020 episode of the television series Curb Your Enthusiasm, "Beep Panic".
- A 2023 Japanese song, Algernon, by Yorushika.
Further stage and radio adaptations have been produced in France (1982), Ireland (1983), Australia (1984), Poland (1985), Japan (1987, 1990), and Czechoslovakia (1988).[42]