Marie Lorena Moore was born in Glens Falls, New York, and nicknamed "Lorrie" by her parents. She attended St. Lawrence University. At 19, she won Seventeen magazine's fiction contest.[1] The story, "Raspberries," was published in January 1977. After graduating from St. Lawrence, she moved to Manhattan and worked as a paralegal for two years.
In 1980, Moore enrolled in Cornell University's M.F.A. program, where she was taught by Alison Lurie.[2] Upon graduation from Cornell, Moore was encouraged by a teacher to contact literary agent Melanie Jackson, who agreed to take her as a client. In 1983, Jackson sold Moore's collection Self-Help, almost entirely stories from her master's thesis, to Knopf.[2]