- Lesbianism – The book describes the way lesbians lived in New York City, Connecticut and Mexico during the 1950s through 1970s.
- Racism – The landlord who hangs himself, the ice-cream episode in Washington, D.C., and the increased suspicion during the McCarthy era all contribute to highlight the theme of racism.
- The mother – Lorde's difficult relationship with her mother, whom she credits for imbuing her with a certain sense of strength, pervades throughout the book.
- McCarthyism and the Rosenbergs are also mentioned.
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