Wise Blood began with four separate stories published in Mademoiselle, Sewanee Review, and Partisan Review in 1948 and 1949.
Originally committed to Rinehart & Company, O'Connor's agent and Robert Giroux convinced Rinehart to release the novel, and it was published as a complete novel by Harcourt, Brace & Company in 1952.[4] Signet advertised it as "A Searching Novel of Sin and Redemption."