- Johnny Depp as Gilbert Grape
- Leonardo DiCaprio as Arnold "Arnie" Grape
- Juliette Lewis as Rebecca "Becky"
- Darlene Cates as Bonnie Grape
- Laura Harrington as Amy Grape
- Mary Kate Schellhardt as Ellen Grape
- Kevin Tighe as Kenneth "Ken" Carver
- Mary Steenburgen as Betty Carver
- John C. Reilly as Tucker Van Dyke
- Crispin Glover as Robert "Bobby" McBurney
- Penelope Branning as Becky's Grandma
- Libby Villari as the Waitress[1]
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