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Marie St. Clare
Augustine's wife, who was once a popular Southern belle. Now, she is a hypochondiac who cares about no one but herself. She disapproves of her husband and daughter's close relations with the slaves and sells Tom and eleven others when her husband dies.
Eva St. Clare
The five-year old "Little Eva" is characterized as a beautiful, angelic child. She and Tom become best friends, and they are bonded by the common love they have for those around them. Eva dies young, and upon her death she both asks the slaves to be good Christians, and has her father promise that he will free them.
St. Clare's northern cousin who comes to help him run the plantation affairs. St. Clare buys Ophelia a slave so she can have a "missionary project" of her own. At first Ophelia dislikes Topsy, but her feelings of racial superiority are eventually broken by the friendship she forms with the needy little girl.