Ozick's fiction and essays are often about Jewish American life, but she also writes about politics, history, and literary criticism. In addition, she has written and translated poetry.
Henry James occupies a central place in her fiction and nonfiction. The critic Adam Kirsch wrote that her "career-long agon with Henry James... reaches a kind of culmination in Foreign Bodies, her polemical rewriting of The Ambassadors."[8]
The Holocaust and its aftermath is also a dominant theme. For instance in "Who Owns Anne Frank?"[9] she writes that the diary's true meaning has been distorted and eviscerated "by blurb and stage, by shrewdness and naiveté, by cowardice and spirituality, by forgiveness and indifference."[10] Much of her work explores the disparaged self, the reconstruction of identity after immigration, trauma and movement from one class to another.[2]
Ozick says that writing is not a choice but "a kind of hallucinatory madness. You will do it no matter what. You can't not do it." She sees the "freedom in the delectable sense of making things up" as coexisting with the "torment" of writing.[11]