- The novel is a focus of attention in Jane Austen's 1817 novel Northanger Abbey, which satirises it.
- In Walter Scott's novel Waverley (1814), Scott humorously references Udolpho in the introductory chapter while meditating appropriate subtitles for Waverley.
- The Veiled Picture; or, The Mysteries of Gorgono (1802) is a chapbook abridgement of it, preserving most characters and plot elements but dispensing with details and descriptions.
- The Castle of Udolpho is mentioned in a letter from Rebecca Sharp to Miss Sedley in William Thackeray's 1848 novel Vanity Fair.[10]
- The Castle of Udolpho is mentioned in the defense attorney's speech in Fyodor Dostoevsky's 1880 novel The Brothers Karamazov.[11]
- BBC Radio 4 has broadcast two adaptations. The first is a 1996 two-part version by Catherine Czerkawska starring Deborah Berlin as Emily and Robert Glenister.[12] The second is a 2016 one-hour piece by Hattie Naylor with Georgia Groome as Emily.[13]
- In 2007, The Mysteries of Udolpho appeared as a graphic novel in the Gothic Classics: Graphic Classics series.[14]
- A dramatisation by Carole Diffey was published in July 2015.
- In series 1 episode 12 ("Homefront") of Young Justice, the Mysteries of Udolpho was the book used to open a secret passage in the League's library. Several characters in the series are seen reading it.
- In Henry James's 1898 novel The Turn of the Screw, the second sentence in Chapter 4 reads: "Was there a 'secret' at Bly – a mystery of Udolpho or an insane, an unmentionable relative kept in unsuspected confinement?"
- In Anthony Trollope's Framley Parsonage (1860), a room for interviewing debtors at the London office of solicitors Gumption & Gazebee is likened to the torture chamber at Castle Udolpho.[15]
- In Edgar Allan Poe's short story "The Oval Portrait" (1842), "Mrs. Radcliffe" is mentioned in an allusion to The Mysteries of Udolpho.
- In Emily of New Moon by Lucy Maud Montgomery, Emily mentions having read The Mysteries of Udolpho when exploring her aunt's strange, "gothic" house.
- In Herman Melville's novella Billy Budd, Sailor (1924) the narrator says that an incident "is in its very realism as much charged with that prime element of Radcliffian romance, the mysterious, as any that the ingenuity of the author of the Mysteries of Udolpho could devise."[16]
- In Frances Eleanor Trollope's "That Unfortunate Marriage" (1888), "And may one ask where she is? It is not, I presume a Mystery of Udolpho!".
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