Christopher Rawlence wrote the libretto for a chamber opera—directed by Michael Morris with music by Michael Nyman—based on the title story. The Man Who Mistook His Wife for a Hat was first produced by the Institute of Contemporary Arts in London in 1986. A television version of the opera was subsequently broadcast in the UK.
Peter Brook adapted Sacks's book into an acclaimed theatrical production, L'Homme Qui..., which premiered at the Théâtre des Bouffes du Nord, Paris, in 1993. An Indian theatre company performed a play entitled The Blue Mug, based on the book, starring Rajat Kapoor, Konkona Sen Sharma, Ranvir Shorey, and Vinay Pathak.
The Man Who, an album by the Scottish indie pop band Travis, is named after this book.[9]