In June 2004, 20th Century Fox acquired the feature film rights to the book. In April 2007, director Chris Columbus was hired to helm the project. The film, titled Percy Jackson & the Olympians: The Lightning Thief, was released in the United States on February 12, 2010 and had Logan Lerman as Percy Jackson, Alexandra Daddario as Annabeth Chase, Brandon T. Jackson as Grover Underwood, Jake Abel as Luke Castellan, and Pierce Brosnan as Chiron. The film received mixed reviews from critics upon release and grossed $226 million at the worldwide box office. A sequel, Percy Jackson: Sea of Monsters, was released in 2013.
On June 28, 2005, a 10-hour and 25 minute audio book version, read by actor Jesse Bernstein, was published worldwide by Listening Library.
Kirkus Reviews magazine said, "the narrator’s voice lends a refreshing air of realism to this riotously paced quest tale of heroism that questions the realities of our world, family, friendship and loyalty". AudioFile Magazine praised the audiobook, "adults and children alike will be spellbound as they listen to this deeply imaginative tale unfold." School Library Journal both praised and criticized the audio book saying "Although some of Jesse Bernstein's accents fail (the monster from Georgia, for instance, has no Southern trace in her voice), he does a fine job of keeping the main character's tones and accents distinguishable".
A one-hour musical aimed at young audiences was planned to hit the road on a nationwide tour in September 2014 following a stint in New York City in 2014. A two-hour version of the musical previewed Off-Broadway on March 23, 2017 at the Lucille Lortel Theatre. It officially opened on April 4, 2017, and ran until May 6 of the same year. On June 20, a cast recording was released on the Broadway Records label. In August 2017, it was announced that the two-hour long production would be going on a national tour beginning in the fall of 2018.