Several film adaptations of the novel have been made:
- Feu Mathias Pascal, a 1925 French silent film directed by Marcel L'Herbier.
- L'Homme de nulle part (The Man from Nowhere), a 1937 French film directed by Pierre Chenal. An Italian-language version, under the title Il fu Mattia Pascal (The Former Mattia Pascal), was simultaneously directed by Chenal.
- Le due vite di Mattia Pascal (The Two Lives of Mattia Pascal), a 1985 Italian film directed by Mario Monicelli.