- Harry Hope: Widowed proprietor of the saloon and rooming house where the play takes place. He has a tendency to give free drinks, though he constantly says otherwise
- Ed Mosher: Hope's brother-in-law (brother of Hope's late wife Bess), a con-man and former circus man
- Pat McGloin: Former police lieutenant who was convicted on criminal charges and kicked off the force
- Willie Oban: Harvard Law School alumnus
- Joe Mott: Former proprietor of a gambling house
- General Piet Wetjoen: Former leader of a Boer commando
- Captain Cecil Lewis: Former Captain of British infantry
- James "Jimmy Tomorrow" Cameron: Former Boer War correspondent who is constantly daydreaming about getting his old job back again tomorrow (hence his nickname)
- Hugo Kalmar: Former editor of anarchist periodicals who often quotes the Old Testament
- Larry Slade: Former syndicalist-anarchist
- Rocky Pioggi: Night bartender, who is paid little and makes his living mostly by allowing Pearl and Margie to stay at the bar in exchange for a substantial cut of the money they make from prostitution, although he despises being called a pimp
- Don Parritt: Teenage son of a former anarchist
- Pearl: Streetwalker working for Rocky
- Margie: Streetwalker working for Rocky
- Cora: Streetwalker, Chuck's girlfriend
- Chuck Morello: Day bartender, Cora's boyfriend
- Theodore "Hickey" Hickman: Hardware salesman
- Moran: Police detective
- Lieb: Police detective
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