- Leonardo DiCaprio as James Gatz / Jay Gatsby, a mysterious millionaire who hosts wild parties at his house with the hope that his former lover Daisy will return
- Tasman Palazzi as young James Gatz
- Callan McAuliffe as teen James Gatz[8]
- Tobey Maguire as Nick Carraway, an aspiring writer, Gatsby's friend, and the film's narrator
- Carey Mulligan as Daisy Buchanan, Gatsby's former lover, Tom's wife, and Nick's cousin
- Joel Edgerton as Tom Buchanan, an old money socialite who hates Gatsby because of his new money status and relationship with Daisy
- Jason Clarke as George Wilson, Myrtle's husband and owner of a gas station in Valley of Ashes
- Amitabh Bachchan as Meyer Wolfsheim, a gambler who met Gatsby in 1919[9]
- Isla Fisher as Myrtle Wilson, Tom's mistress and an ambitious social climber
- Elizabeth Debicki as Jordan Baker, a golf star and Daisy's best friend
- Jack Thompson as Walter Perkins, a doctor at the psychiatric hospital where Nick is a patient[10]
- Adelaide Clemens as Catherine, Myrtle's sister[11]
- Richard Carter as Herzog, Gatsby's butler
- Steve Bisley as Dan Cody, an alcoholic millionaire yacht owner that Gatsby met in his teenage years
- Felix Williamson as Henri[8]
- Barry Otto as Benny McClenehan
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