Main characters
- Karin Schluter quits her job as a service representative to return home to Kearney, Nebraska to care for her comatose brother.
- Mark Schluter has a mysterious truck rollover on a deserted country road and eventually comes out of a coma suffering from a variety of delusions.
- Gerald Weber is a popular writer of books on neurology who answers a personal email from Karin requesting that he come to Nebraska. Weber may be a partial fictionalization of Oliver Sacks, 1933–2015, who was a neurologist, best-selling author, and professor of neurology at NYU School of Medicine. Sacks was the author of a number of nonfiction books, beginning with Awakenings (1973) and The Man Who Mistook His Wife for a Hat (1985), which use case histories interwoven with explanatory narrative to describe a range of brain conditions that result in unusual manifestations of neurologic deficits, in much the way Weber does in The Echo Maker.
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