- Christine de Pizan refers to several of the stories from The Decameron in her work The Book of the City of Ladies (1405).
- The title character in George Eliot's historical novel Romola emulates Gostanza in tale V, 2, by buying a small boat and drifting out to sea to die, after she realizes that she no longer has anyone on whom she can depend.
- In the 1994 movie My Summer Story, Ralphie does a book report on The Decameron and gets in trouble with his teacher for doing so.
- The tales are referenced in The Borgias in season 2, episode 7, when a fictional version of Niccolò Machiavelli mentions at a depiction of the Bonfire of the Vanities that he should have brought his friend "the Decameron" who would have told the "one-hundred and first" tale.
- Season 1, episode 5 (2013) of the American TV series Da Vinci's Demons portrays a theatrical adaptation of stories from The Decameron.
- Inspectors find a pocket edition of The Decameron on the body of a dead man in the Sherlock Holmes story A Study in Scarlet.
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